An expression of the Mannerism of Giorgio Vasari and Bernardo Buontalenti, the church has origins dating back to a fresco linked to prodigious events in the 16th century, depicting the Madonna and Child and attributed to Paolo Schiavo or a young Masaccio. It was built thanks to popular devotion and the munificence of the Naldi family.
Designed by the painter Domenico Cresti otherwise known as the "Passignano," the interior presents a refined architecture that stands out for its elegance and balance. The church has a Latin cross plan, with the main nave covered by trusses and side chapels with cross vaults, forming the transept. In the center of the altar is the obsequious fresco of the Madonna and Child, unfortunately damaged during the detachment from its original position. The left altar, on the other hand, features a Crucifixion between Saints Jerome and Francis, a work by Cosimo Gamberucci from 1609.
Today, the shrine continues to be an active place of worship, maintained by the "Company of Odd Fellows," which preserves its centuries-old structure and traditions.
